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Running head: DISSERTATION PROSPECTUS1Awareness, Attitudes, and Barriers to the Effective Management and Control of SCD in IllinoisDepartment of Public HealthDissertation ProspectusDISSERTATION PROSPECTUS2Topic: Awareness, Attitudes, and Barriers to the Effective Management and Control of SCD inIllinoisProblem StatementSickle cell disease (SCD) is a debilitating illness associated with acute and chroniccomplications that present a substantial number of visits to an emergency section andhospitalization of a patient (Santos, Jones, Wakefield, Grady, & Andemariam, 2016). Despitebeing a blood disease, the SCD affects the entire body and pathophysiology sets in early ininfancy (Manwani & Frenette, 2013). The key features of SCD are vaso-occlusion and chronichemolytic anemia (Manwani & Frenette, 2013). Auto infarction, due to sickling of theerythrocytes, leads to a non-functioning spleen, which results in functional asplenia thatincreases the risk of invasive attacks since the spleen is unable to screen bacteria from circulation(Brown, Dada-Adegbola, Trippe, & Olopade, 2017).Due to immune defects in SCD, patients are prone to infections mainly from encapsulatedbacterial microorganisms, such as Salmonellae, Haemophilus influenza, S.pneumoniae, andparasitic infections. Fox (2016) posit that the major cause of fever in children is viral infectionsand the rate of occurrence of significant bacterial infections is 16%. Over the year, the death rateof SCD has ...


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