Health & Medical : Pharmacology Assignment

Running Head: PHARMACOLOGY DISCUSSIONPharmacology DiscussionNameInstitution AffiliationDate1PHARMACOLOGY DISCUSSION2The Steady-State Level of a DrugThe steady-state level of a drug is said to be reached when the input rate of a drug isequal to its elimination rate. A steady state takes place when the drug amount in the plasmabuilds up to a concentration that is effective therapeutically and as long as there is regular dosingthe steady state will remain constant as the drug will remain active. It takes about four to fivehalf-lives to get to a steady state, of which a half-life is the time taken for half the amount of adrug that is administered and reaches the plasma to be eliminated (Ito, 2011). Drugs that have alonger half-life such as warfarin will, therefore, take a longer period to reach a steady state.Sometimes a loading dose is given to reach a steady state quickly.Importance of a Drugs half-life to Healthcare ProvidersHalf-life is significant to healthcare providers as it assists them in determining how muchamount of a drug and when the doses require to be in administered for the drug to achieve thetherapeutic effects. Half-life also helps in the interpretation of adverse effects that occur someconsiderable time after the start of regular treatment like with Benzodiazepines. Besides, it helpsin deciding the need for an initial loading dose when beginning treatment with drugs that havegot a narrow therapeutic index such as Digoxin and Amio ...


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